I travel to/from BC and Denver quite often (Sierra, 6.2L) sometimes towing a smallish (under 4000 ibs) trailer and sometimes, not. I travel the major highways and, depending on whether the trailer is ...
You need to be using tow/haul mode on hills while towing. This will change the shift points and keep it out of overdrive and should lock up the torque converter on down hills all g with downshifting to help keep you at speed.