My father has a 2005 Dodge SRW 3500 with the low HP engine. He gets 24 empty. If you need duals I would choose the Ram over the Ford because with Ram I believe you can choose duals and still get a 3:42 rear axle so I wouldn't expect the fuel economy to drop as much. My srw Ford is not great on fuel and the 3:73 gears and smaller tires of the dually would likely make it terrible.
Thanks for the reply. My Ram has 3.73 gears, 4x4, crew, longbed and the 325/610 high output engine. It also is an automatic so I am pleased with the 20-21 mpg at a steady 65 mph mileage. And the power is more than pleasing, it is amazing. Carried a 4000 pound cabover camper so the dually was much more stable. But still needed air bags and overload spring suspension bumpers. After that it worked 'just right'. I think the Ford has perhaps a little better stock springs for stability. With the camper on I got 13-14 mpg and towing our 30 foot TT now I get 12-13 mpg. I am willing to trade a little mileage for stability and a little better towing gearing for power in the mountains. I know a lot of folks tow fifth wheels with pin weights of 2500 or more pounds with 250/2500 trucks; if they tried out the dually I am sure the experience would be even more stable.