If you are worried about the weight, you might ask the reverse question: Do I need an F250? First you can order an F350 with a 10k door sticker, and these along with the F250 are regulatory creations. We got 50 states, some territories and thousands of other regulatory bodies. I have a F250 because I visit NJ from WV every other week (My wife moved all over the country with me, and now wishes to go home and visit since we now live close to the Garden State).
So due to the rules of hammer lanes, parkways, neighborhoods, and MTag, I require a truck with the F250 badge on the side, and non commercial tags (I could save about $10 a year in WV with B, commercial tags for 10k wieght).
Without those requirements, I would get a mid-spring rated F350 instead of my F250 with the max springs. Of course I could change out the wife and get the truck I want, but she tells me that I cannot afford to trade her off.
As far as towing and ride, I don't think I could tell the difference without the badge on the side. The 350 is as an earlier poster stated, just a touch higher at the cab.