My maiden voyage on my 00 Ex w/V10 and 4.30 took us from IL to FL and back with no problems. Did that twice and other shorter trips. I drove slightly faster (rpm torque peak) to keep the trans from downshifting as much on the smaller hills. Another lesson learned was downshift the trans on steep declines to let the engine brake the load putting less strain on the brake system. It only took 2 brake applications on a steep one to get my new brake pads/rotors to fade. Never had problems out of the brakes after that. I saw some of Mike's posted dyno's for his tunes with headers and they were impressive you'll be fine!
