How to replace wood floor in slide out?

Yes it can be done I've replaced three. Bedroom slide was the easiest. Removing all the kitchen cabinets sink stove fridge and entertainment center was a little more work. I did the dinnet loveseat first, it needed it most. Took my time, lets say I was learning along the way. One thing I was concerned about was realigning the slide to the slide mechanism so I cut spacers out of 1inch aluminum pipe and left one bolt on each side to keep the alinement and just noched around them when installed the new panel. After the floor was in and secured I filled the void with silicone. Another tip take measurements of the interior dimensions before removing the existing floor.

I replaced the OSB with marine plywood, laminated pieces since I couldn't get any longer than 8 ft and used epoxy truck bed liner to seal the bottom of the new flooring.

Good luck.