Installing scissor jacks???

I would not use bolt-on on a tubular frame. A heavy tubular frame where the tube is strong enough not to collapse could be a different story. If you can get the nuts inside the outer wall of the tube could work. I would still be concerned over ripping tube out.
Internior corrosion would be my next concern bolting straight through.
Yes, even with self tapping screws corrosion can be an issue if some type of corrosion protection is not used.