is 2500 +/- each way road trip pratical in 10 days?

Wife and I use to drive a big truck and before they changed the hours of service rules we drove non stop except for fuel and once every 5 hours to swap drivers and going from Virginia to California and back in a week was done a few times but after each trip we were out of hours. But that was in a big truck and we cruised on cruise control at 55 mph. Now that we're retired we choose not to.