I have done right at 1000 miles in 15 hours with 2 pee breaks, one of which was also a food/fuel stop, but I had to fall out of the truck at my destination as I was too stiff to move at first.
I recently drove just shy of 2400 miles round trip in 48 hours (including all stops and getting new tires on the trailer after one blew in New Mexico) going from CA to TX and back to deliver a car to my son. I did all the driving. I was totally dead by the time we got back and slept the entire next day.
Travel during those trips may have exceeded the speed limit.
With you and wife trading off driving (sleeping as other drives) it would give 5 maybe 6 days at destination but the first would be spent sleeping. You would also need to factor in a full day (at least) of recovery time upon returning home. So it can be done but proably not the most enjoyable trip.
