The only transmission offered in an F-350 from 2011 to 2019 was the 6R140 6 speed transmission. Shifts down from the top 3 gears down into the next lower gear are all close to 30%. The change from 3.73 to 4.30 is a 15% change. So, about on average the 4.30 axle would save an additional downshift when one is already below 6th about 50% of the time. The 4.30 would definitely reduce downshifts from 6th at highway speeds. Only the OP may decide what is worth what to them. However, if the truck only tows a small percentage of the time, it wouldn't be worth an axle change to most folks.