My 2006 and 2017 F350 duallies make 16 mpg empty. Not sure about number on newer one as I drive it empty only to lumber yard short trips, but couple of times driving on those 35 mph highways I have seem computer displaying 25 mpg.
Hard to compare unless you have 2 truck with identical engines/differentials and only SRW to DRW difference, but I don't think the extra wheels lower mpg in % that you can easy measure. More likely wider body can make bigger effect, but with camper that doesn't matter at all.
The lower mpg in my signature is due to the fact that I made several trips to California with 7000lb cargo trailer.
Heading from Vegas toward San Francisco I usually had strong desert winds, that cost me 9 mpg. Coming back with 6-7k of cargo I averaged 12 mpg.