If one would fill tires with ordinary air, it eventually becomes only N2 with a tiny, tiny difference. It would be easy to calculate how long it would take, but the approach to nearly pure N2 is an asymptotical progression.
Just for the purpose of argument, assume that your tire lost 1 psi per day, and you refilled it each day with more air back to the original pressure. One could calculate the amount of loss comprises mostly non-N2 and is replaced with approx. 80% N2.
Of course it can't quite reach perfection but at some point it becomes negligible.
In any case it matters little, and the laborious calculations (read self-torture) gets old quickly. Have fun!