I have towed both and when set up properly the number of axles does not matter. In fact there may be a slight advantage to the single axle as it will not be squirrely because of misaligned tandem axles. A blow out is a bad thing whether it is on the front tire of the tow vehicle or one of the two or four trailer tires. Again, there might be a slight advantage to a single axle as the blown tire will be apparent sooner and do less damage to the trailer than when either the front or rear tire on a tandem axle comes apart. Naturally, GVWR requirements will determine the size and number of axles required to carry the load.