I've have an 8' Lance with no slides, a 9'6" Lance with a dinette slide (usable with the slide in), and a 40' DP with slides (usable with the slide in). I have a Host Everest on order (not usable with slides in).
Obviously, with a MH you want to be able to move around while driving, so it makes sense to get one that's usable with the slides in.
I've seen several people comment that they don't like campers that you need to deploy at least one slide for a quick bathroom stop. Even the big, slow, 36" deep slide on my DP took less than a minute. I feel like it would be a very rare occasion that deploying a single slide (2 in the case of my Everest) would be a hardship for a quick stop.
For those that believe it is a problem, is that your assumption from looking at them, or based on personal experience?
2022 F450
2023 Host Everest
2021 Yamaha YXZ1000R
1987 Honda TRX250R
2002 Honda 400EX
2023 Yamaha Raptor 700SE
2018 Look 24' enclosed trailer