A year and a half in, no problems, no trips for service except oil changes and tire rotations, plus two state inspections.
Tows a 10K fifth wheel well. Mine has the 4.3 rear ends. I do not normally lock out 9th and 10th gears, just let the transmission do its thing.
My last truck was a 2012 6.7 diesel. The 2022 7.3 does not pull as well, and it takes more brake applications going down hill. I had an aux tank on the diesel, and I have installed an aux tank on the gas. The gas truck is a super cab, so with the 34 gallon factory tank, and the 41 gallon aux tank, at about 8.8 mpg towing, I get a bit over 500 miles of running per day.
A better compromise for me, with the simpler engine and emission controls. However, I will not know if I made the right decision for a few more years. I will just have to wait and see if it is a good high mileage truck.