DO NOT go down 441 to Clewiston! 441 down the east side of the lake is not fit for man nor beast. IMHO. US 27 is much much better road. I don't see how you can avoid Orlando, Ocala is not a good option. I'd stay on I-4 through Orlando to US 27 and then it's an easy drive down to Clewiston. I just came-up that way a few weeks ago. US 441 is ok until you get south of Okeechobee, and from there south it's a nightmare, at least it was the last (and only) time I went that way. Pahokee is the pits. The time I went through there, (I wanted to check-out the campground in Pahokee) I was pulling a 5th wheel and my wife was following in the car, she called on the cellphone and asked, "Where have you taken me?" It was slow, twisty, windy, bumpy, and narrow, and parts were fairly congested. I wouldn't recommend that route to anyone. JMHO