Best route between Columbus OH and Charleston WV

I've also driven between Columbus and Charleston many times over the years, with family in Ohio and all. I take US-33 all the way to I-77 at Ripley, WV, just north of Charleston. US-33 used to be horrible, but today it is nearly all 4-lane divided highway, with just enough 2 lane to keep you from falling asleep, mostly between Lancaster and Athens, Ohio, and to cross the Ohio river. In fact, we'll be making that trip both ways in a couple weeks to visit some of that family.