Nope, I-10 is the most direct and quickest. In Louisiana get on I-12 to bypass New Orleans then back on I-10. We've been down it and back many times. If you were going to North NM or CO I'd suggest I-10 to Mobile then north to I-20 to Dallas then US 287 to Amarillo and then into NM via I-40.
Not a whole lot to see on any of these routes until you get to western TX. Houston is the only major city it will take you 3 hours or so to get thru it. Do not get on the HOV lanes in Houston they may lead you to places you don't want to go.
