Black Canyon of the Gunnison to Glenwood Springs, CO

Pulling a fiver, you'll want to go to Grand Junction, take the Clifton turnoff, and get onto I-70 all the way to Glenwood.

You could come the scenic route over McClure Pass, but it won't be worth the windy climb.

And if you have plans to bike the river bike path through Glenwood Canyon, be aware it's partly closed from flooding.