Well if you are on a bike 160 is a fun ride. So take 65 up to 60 east it is a great road now, you do NOT want to cross the Miss river on 60! Take I 57 NE get off on first exit past the Miss river & go south through Cairo then back on 60 across the Ohio river as it is ok. It is only a few miles out of your way & worth it if you like the mirrors on your rig. I take 62 in KY which is a slow 2 lane road.
Now on your trip you will go past 2 lambert's one at Ozark MO. & #2 Sikeston MO. I think Sikeston has better food. If you have never been lambert's is a must stop. If you stop at Ozark get there at 10:30 unless you want a 2 hr. wait as they get at least 10 busses a day going to Branson.
Sorry forgot at Wickliffe Ky we would take 286 to 62 still slow 2 lane road.