Sure, you could take US 441 near Athens, GA, then US 129 to Macon and US 80 to Columbus and on to I-85 (or US 280 on up on Opilika). I never took any of these routes to avoid Atlanta, but I have towed on every segment of the route--just to be clear: every mile of each segment.
I am not making this as a recommendation. I have towed through Atlanta many times without incident or delay, but you do have a choice, and depending on the particular trip it is one I might well make.
My great grandparents came to Texas from Banks County Georgia; my best college friend lived in Atlanta; my wife's favorite uncle lived in Columbus--we have made many trips to North Georgia with our trailer in tow.