The route we would take always missed Guad,(and PV of course) on our way to Villa Corona while traveling southeast. These are secondary roads you share with the trucks carrying sugar cane and the like, very rural, miles away from the big city of Guad. Continuing after our short stay near Villa Corona, we would join the route to Colima, still missing Guadalajara. Only once, when we were headed for Ontario and Quebec did we get close to Guad with our rig, because we needed to take the existing periferico to access the road to Zacatecas, and beyond. That time one really needed to pay attention as to where our road north left the bypass road. I think only a fool would drive right through the big city (although we were on the coast one year and drove through the Malecon at Puerto Vallarta).