Crossing the USA from Tampa, FL to Western USA and back

Do a Google search for `_______ tourism' and put the State, city, area or whatever in the blank space and read what the specialists recommend.
Such a trip could take a lifetime!
Adventure Caravans takes the entire month of September just to make the great circle tour of the western national parks.
You may not realize how BIG is the US if you are from the East. For example after driving 1000 miles you will make it as far as St. Louis or Oklahoma and that's 1/3 of the way!