We have driven a 27 ft class C towing a Jeep Wrangler over Towne's Pass between the Panamint Valley and Death Valley many times (but usually in the winter 1/2 of the year). It is a slow climb and long descent. I'd often have to get down to 1st gear on the Panamint Valley side. Be sure to use your gears and engine braking to keep your speed down on the long descent into DV. Temperature is likely to be anything from warm to very hot in late September and nighttime doesn't cool down that much that time of year. Late summer thunderstorms can cause heavy rain, so keep a check on weather. If you eat at the Panamint Springs Restaurant and Noah Bricker is waiting tables, say "hi" from us (though we haven't seen him in several years).