drive from Custer SD to Lake McConaughy NE can we?

We travel that way a least twice a year in a 43ft motorhome pulling a jeep. We usually take 385 to 26 and catch I80 at Ogallala because it is a nice road. This route will take you past some of the rougher countryside out west by Bridgeport and takes you near Lake McConaughy near Ogallala. We have taken hwy 2 in the past also. Hwy 2 takes you through the sandhills of western Nebraska and many small unincorporated towns, but watch your gas because filling stations are far and few between.