drive from Custer SD to Lake McConaughy NE can we?

I travel from the east (Mullen) on 2 and 61 every year with a 5th wheel and boat combo. They are good 2 lane roads and easy to travel on. The scenery is typical sand hills if you like that. Most towns are small and fuel is scarce. There is a truck stop at the junction of 2 and 61 but nothing south of there until Ogallala.