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One more possible to consider is route 8 which cuts through a beautiful part of the Adirondacks through Speculatorand ends in Rome. You can pick it up from Route 9 in Chestertown or from 28 in Weavertown. I spent the biggest share of my working life in Rochester and always used route 8 to visit my home area.
That is the route I would take after visiting Saranac Lake, onto The Wild Center and Adirondack Museum. After Blue Mountain I would drive west on Rt. 28 thru Old Forge then over to 90 west to Rochester.
