Depends on how fast you want to get there. US Hwy 41 will eventually lead you to the Naples area. It's the old pre-Interstate main route. We took it from New Jersey when I was a very young kid. The road past Naples where it cuts across to Miami was infamous for people falling asleep and vering into the deep canal that parallels the highway, still does for that matter. But the highway dept has put up lots of barricades since then.
Hwy 41 crosses I-10 just before you get to I-75