From Tyler, TX to Pensacola, FL,

And another Yes. Just off the route mentioned above, there is the town of Natchitoches, LA (pronounced NACHA tush) which is worth a visit, even an overnight stop. On the other side of the River there is Natchez, MS with many Ante Bellum homes. Not far off the route near Mobile is the Bellingrath Gardens and right on the route there is the Battleship Alabama. Near Pensacola there is the Naval Air Station and the Gulf Islands National Seashore including the campground at old Fort Pickens.

These are just a few that come to mind. I'm sure there are many others.

Yes and Yes!!!

Just one good example: Take US 64 down to Mt. Enterprise, TX where you could pick up US 84 E all the way to Collins, MS. There take US 49 to Hattiesburg where you pick up US 98 all the way to Mobile.

As for me, I would take I-65 down to I-10 as there is no better way to get on to Pensacola, but you could take US 98 if you are in no hurry at all.

There is a great campground at Vidalia, LA across from Natchez "Riverview". I'll be staying there in May on a trip back from Pensacola (Fort Pickens). Also just off the highway there is Natchez State Park.

We have also camped at Hattiesburg at a nice rural campground--forget the name just now. Same for a rural campground near the MS AL state line, near Wilmer, AL.

This route is very familiar to me I've made it many times. If you have any specific question, PM me and I will try to be of help. I could even give some different route suggestions. I've been many different ways from East Texas to Pensacola and other parts of Florida.

BTW, I'll be stopping in Michigan in June on the way to Ontario.