From San Diego to Malibu is mostly crowded city driving. From Malibu to Oxnard it on the coast so you get ocean on your left until Point Magoo NAS. There it merges with 101 and you get more time with the ocean on your left until Gaviota where 101/1 turn inland. There is an off ramp for 1 that goes through the inland commumities of Lompoc and Guadalupe then 1 reunites with 101 in Santa Maria.
You are inland until Pismo Beach where you get an ocean view for a couple miles. In San Luis Obisp get off on the Santa Rosa St. exit (Morro Bay). That is where 1 leaves 101 for the coast (15 miles away). From Morro Bay to San Simeon the road it very good, no trouble for any size vehicle. Once past Ragged Point (about 5 miles north of San Simeon) the road narrows and has lots of curves. From this point on is where some people will not take large vehicles and others who are more comfortable with their rigs have little or no concerns.
Time of year here is also a factor. Spring and summer tends to have dense fog for days at a time. Fall and winter are less likely to have long periods of fog. Campgrounds are moatly state and national parks with a few private parks.
Once into Monterey the road opens up again and is not so curvy and narrow. From this point I'm not as familiar as the middle portion of the road.
Safe trip.