Hyw 199 from Grants Pass to Crescent City California

x2 what mtnbbud said.
There are a couple tight spots, but big rigs run up and down that road all the time. Just go slow and enjoy the scenery (you'll be along the Middle Fork of the Smith River).

The smoke is from the Flat Fire (named for Oak Flat CG along the Illinois River, near where it started) that is just a couple miles south of Agness. Presently, most of the smoke is going south(ish) which would likely impact Hwy 199 (i.e.; there will be smoke)

Have fun.