I-465 West Or East Best Route To Bypass Indy ??

I'd avoid I-465 on the West side of Indy if it was Indy 500 weekend, other than that, it doesn't make much difference. Depends on where you're coming from and where you're headed for. I've driven around Indy several times on my way west or north from Cincinnati, and I've never run into much traffic. Certainly nothing like Atlanta.