If you are traveling weekdays between 6:30 AM AND 8:00 PM the turnpike option is a great choice. I travel the area at least once a month.
Scranton has construction going on right now and the lanes are a little narrower than normal. IN addition the area between Clark's Summit and Wilkes Barre can be very congested. In fact the speed limit is lower through the area because of construction and the congestion.
Contrast that to the turnpike which has little traffic and very few exit ramps. I would use the turnpike in a heartbeat. Just because of the less headaches and confusion.
When you exit the turnpike in Wilkes Barre there are gas stations right at the exit so you can fill up and go onto 81.
Weekends and after 8 PM I would stay on 81
PS I was through there 10 days ago.