I'm been sounding the alarm about that stretch of road for about 3 years now, and seems some folks just don't listen. For whatever reason (maybe because they have never actually driven it towing something) they think the problem is construction. Construction is not the problem. The problem is, the road is just horrid... bumpy. We traveled that road twice in the last 3 years going to Panama City City Florida from Central Indiana. The last time I was determined to take an alternate route, but somehow found ourselves right back on I-65 South. The inside of the camper looked like a bomb exploded after we got through there.
Coming back, we took I-75 and on up to Cincinnatti and then over to Indy and back home.
Some folks just don't get it. Maybe driving an automobile or a vehicle with an air-ride suspension, you'd not notice it so much. But put a camper on the back of a one-ton and it's a whole different ball-game driving that road.
I-75 is your best work around.