Iconic USA Drives....List Your Favorite

It's ALL good. Love the place you're in.

WOW ONLY ONE.
Impossible task
I think you should change your post to routes that can be done in a large RV

The ones I really like are hard in a large RV but they are
1) Apache Trail limited to about 25 foot rig in spots unless you are really daring
2) Salt River canyon but not easy in a big rig.
But the Favorite large rig doable route for me is the Natchez Trace from Nashville, Tn to Natchez, Ms slow paced 2 lane tree lined historic beautiful free campgrounds.

Isn't open all year, but the North Rim road from Jacob's lake to North Rim Grand Canyon Lodge.

Blue Ridge Parkway in the fall.

I like to travel the old US Highways, most are two lane.

Staying off the Interstate as much as possible is one of my main likes. Sorry, I can't give you just one.

You can't see America from the Interstate system.

550 from Durango to Ouray Colorado.

Not sure it's iconic, but US 26 from Idaho Falls to Jackson, Wyoming. Gorgeous. In the fall, it's a stunner.

Oh my! Hard to pick just one, but I'd have to say the Beartooth Highway from Red Lodge, MT to Yellowstone's NE gate. http://beartoothhighway.com

My late wife and I traveled it during the first of many camping trips together. It's a beautiful drive. Some don't recommend driving it in a motorhome, but that's exactly what we did, and we enjoyed it going into the Park so much that we took the same route back home after visiting Yellowstone and surrounding areas.

Going to the Sun road in Glacier National Park. Allow a full day & stop at the historic lodges.

US Highway 61 from Duluth MN to Thunder Bay Canada. Cliffs, waterfalls & Lake Superior.