We enjoy 395 heading N. The mountains are beautiful and the drive offers good views of Mt.Whitney. Bishop is a very nice town. We have stayed at Highlands RV on N side of town. Lots of gas stations and a large Von's grocery and K-Mart.
Further N you will pass a lot of spectacular scenery including Mammoth Mt, Mono Lake, Twin Lakes. Beware stopping for gas in Brideport as they have a reputation for being highest gas prices and it's well earned. We fill up in Bishop.
The only climb that is worth noting is just N of bishop; It's a long, steady grade but nothing to worry about if you take it easy. We travel it quite often, towing a 33' 5er. It's a well maintained divided highway. There is another climb past Mono Lake but once again it's not difficult if you take it easy.
There is lots to see/do on 395 if you have time but if just driving through the scenery is worth the drive.