You can cross the Midwest pretty quickly. I would head south initially, pick up i70 and put the petal to the metal. Using stretch breaks every two hours and even a short nap along the way you can easily travel 500mi per day. Santa Fe is a "womens" town! Lots of ladies past child rearing years and/or divorced or widowed have moved there to enjoy the variety and beauty of the area. It is one of the most significant arts oriented cities in the USA. Lots of gallery wine and cheese events, etc. Ghost Ranch is interesting and scenic. April is a cool month in Santa Fe. The trees are just starting to bud out and a few early flowers are beginning. There are three RV parks in the Santa Fe area and my favorite is Santa Fe Skies. Very nice clean restrooms and showers. April will be cool balmy days and chilly nights. Snow on the peaks above the city. You won't need reservations anywhere in April but call ahead early in the day you plan to arrive if you want to be sure. I would spend at least a week in Santa Fe. If you head north April is still heavy snow pack in the Rockies.
