Mass Pike Boston to Venice FL

Not sure where or why you'd hit 78 off 84, i'd take 84 to Scranton and hit 81 then down to 77 and 26, you'd stay completely away from all the nightmares of NYC, Balto-Washington and Richmond.
Longer, but far more scenic and relaxing.

^^^ What they said... kind of

Take 84W to 81S to 77 South.. around Charlotte grab 85 South

When close to Atlanta, get on 75 South right to Sarasota/Venice

My standard route (from Boston area) would be I-90 to I-84 to I-81 to I-77 to I-26 to I-95, and then in Florida A1A to US-301 to I-75 at Ocala.

For variety, I sometimes go I-81 all the way to I-40 to I-75, but this means going through or around Atlanta, which is sometimes not too bad...and sometimes a character building experience.

Another not unreasonable option, though somewhat slower going, is to make your way to the Garden State Parkway and then take the Cape May ferry and Chesapeake Bay bridge/tunnel and head on down e.g. US17 until it intersects I-95. That gives the opportunity to stop at a variety of interesting coastal places, such as Assateague and Cape Hatteras, and avoids the worst of city driving.

If the weather is threatening I get off I/84 at the first PA exit and take US 209 to I/80 to PA 33 to I/78 then to I/81 south (it's mostly flat). This eliminates PA mountains with fog and snow. Nice weather I/84 to I/81.

Anyone go 81 to 66 to 234 to 95 down to FL and then a route down to Venice? 77 is pretty far down 81 before crossing over to 95 and it looks like more miles than 66?

BUKHRN I was thinking 84 and going around Hartford on Charter Oak Br to 91 to 684 to 84 to I think it is 287 to 78 and out to 81. I was definitely thinking we took 66 across to 95 but people are talking about 77 but looks further. NOT SURE of course given I do not have knowledge of doing it that way and it may be a better way.

Best route no question is 81,77, 26, 95.....I have used them all. 66 isn't bad but brings you north of Richmond

According to Google Maps, the I-77/I-26 and I-66 variants are virtually identical in length (they differ by one mile).

The descent at Fancy Gap on I-77 can on occasion be quite foggy. If they have reduced speed limits posted (there are electronic variable speed limit signs in that area), don't ignore them.

RVER wrote:
Anyone go 81 to 66 to 234 to 95 down to FL and then a route down to Venice? 77 is pretty far down 81 before crossing over to 95 and it looks like more miles than 66?

Not since I got slightly smarter in my old age, nothing wrong with 66, i use it myself, but I take 17 which brings you back to 95 farther south, around Fredricksburg, but now that area of 95 is under constuction.
Not sure what your hurry to get on 95 is, but I'd stick to the 81/77 route.

I guess it is 81 to 77 and 95 I like to avoid fog and traffic and that is why I do not go straight down 95, NY, Baltimore and DC traffic is HORRIBLE or at least was but with pandemic may not be so bad? Anyway, if anyone hears of bad roads etc please let me know. I am too **** old to sit in traffic for hours which has happened to us. IF we were traveling alone, we would just get up and get through NY by about 7 so would miss high traffic and also miss rush hour in Baltimore and probably in DC and someone once told me you take a road around Baltimore like 295? on the EAST side? And for DC there is 495m0or 695 something like that and do the Northside of the road, I think. BUT we are not alone so we are going out to 81 via 78 because the 84 all the way out to 81 is one LONG road so changing roads is good and then we end up on 81 lower anyway,near Hershey get on 81. 77 sounds like consensus.