OMG - there's a ton of stuff to see here. It's a bit dicey through some of those mountains out of Mesa Verde, but when we did that area, we came out I-40 and up through Gallup to Farmington (where we did some fishing there), course you can do that in Durango too - that area is fabulous for trout fishing - get a guide, it's worth the price.
So if you're coming through I-40, then south of Amarillo, stop at the
Palo Duro State Park - beautiful scenery there. Traveling into Oklahoma here are some of my favorite stops:
Red Rock Canyon State Park - this time of year the trees will be turning and it's beautiful - do call ahead, they only have a very few full-hookups but if you're coming through during the week, you can probably get a site. This was a place that was cool and water was always available when the covered wagons came through and you can still see the ruts from the wagon wheels.
Red Rock is close to the city if you want to come into some fun eats and events there.
Here's a link to some things to do in Oklahoma City (no I don't work for the chamber, but I should!)
Next - depending upon going north or south into AR, here's some suggestions:
Going North - stop off at
Osage Hills State Park and trek to the
Tallgrass Prairie Preserve and drive around to see buffalo roam the prairie. This time of year, the color will be out, so be prepared for some beautiful color and the bison will be rutting. There are hikes you can take (short) and beautiful countryside through the foothills of the Ozarks.
Going straight East - Stop off at
Greenleaf State Park which is a quiet park close to Tenkiller (you can do some pretty good trout fishing below Tenkiller Dam), and some crappie and bass fishing at Greenleaf Lake.
Going South - If you are in the neighborhood and don't stop at this park you should be shot! This is the state's most popular park at
Beaver's Bend State Park and they have some pretty spectacular sites. Fern can be a little tricky to get into (with your big rig, I wouldn't recommend that campground). But Buckeye and Cypress are great campgrounds for bigger rigs. Fern is higher from the river's edge and Buckeye and Cypress are almost level with the river's edge.
Here's some shots of our trip there last fall, do make reservations as they fill up fast - like reservations now! Buckeye is the only one that takes reservations, but that's OK cause that's where you will want to stay.
Here's a map of the campground and although the park looks small, it's really filled with trees and the sites are very private.
BTW, all the links will take you to the sites where you can click on reservation info and maps to help you navigate through.