toed, you are right that there is no alternative route during this current wave of blizzards. But in an "ordinary" snowstorm, there are times that you can safely do an end-run around the closures, if you head east from Bishop and then north through Nevada.
It all depends on the snow level and the wind. If the snow level is (let's say) 5000 feet, 395 may be closed but the Nevada roads might not be.
Having said all of that, my first instinct in bad weather is to stay home, if at all possible. I have towed my trailer in slush and snow, and it is not fun.