I-80 highest elevation is between Cheyenne and Laramie, at ~9600 feet before you descend into Laramie. Otherwise it will be rolling terrain for most of the trip across WY. As previously mentioned, head winds will be an issue. Also as mentioned, snows come in and usually melt off quickly. But there can also be ground blizzards that will close hundreds of miles of I-80 at a time.
I-70 from Denver to points west will have a lot of ups and down, starting immediately west of Denver with a significant climb, a bit of a levelling off, and then a steep descent of Floyd Hill into the Idaho Springs area. Some flatness for a bit until you get to Georgetown area, where shortly after you'll start the climb to the Johnson/Eisenhower tunnels. Then the very long descent into Dillon/Silverthorne, and just when you think it couldn't get steep again...it does. The climb up Vail Pass and the the descent into Vail and the Vail Valley area. NOW it becomes mostly downhill all the way to GJ and on in to Utah.
April is one of the snowiest months in Colorado and, like Wyoming, they can move in, dump a load of snow and then it's plowed and cleared. Either way, watch the weather and be prepared to hunker down someone for a day or 2.