I'm with Mayor30, depending on where you are leaving from in New Jersey, you want to avoid the Penn Turnpike. It is a hefty toll. I pay almost $30 just to go from New Jersey to the Harrisburg area. It will probably cost you almost almost $50 to get to where I-70 branches off near Pittsburgh. You can check the toll calculator at the Penn Turnpike website.
If you take I-80, stay straight toward Akron when you get to Ohio. That will take you to I-71 that you take south to Columbus.
Another idea, depending on time and where you want to go, is take I-81 south through Virginia than I-40 across the country.