North Myrtle Beach to Nashville, TN

your route looks good.

i-40 from asheville heading east can be a pain right now due to construction etc. but is usually always pretty heavy traffic.

wife and i went to gatlingburg area this past september and i-40 west of asheville into tenn was a very good calm traffic drive.

i would always avoid the charlotte area if possible. traffic is bad 7 days a week

I make this run a lot and I think you have it right. The 501 is THE way to miss all the little towns/speedtraps. Its barely used and a very pleasant drive imo.

I'd let timing tell me where to spend the night. you Do Not want to go thru Asheville or Knoxville during rush hour.

In my opion your stated route would be what I woud take. We go to Tabor City when we visit the Myrtle area and that is mostly what we take. I think going to 74 would take a little longer.

Myrtle to Nashville would be a long day but you could make it. I refuse to push myself that hard anymore so a good stop would be the Hendersonville/Asheville area. I'm just west of Newport TN and it takes us near 8 hrs. to get to Tabor City. I don't drive but 65-70 mph. There are quite a few parks to choose from.