I have driven from Los Angeles to Ft. Stevens on Hwy 1 where available and 101 between. It's very pretty but it is very tiring. I don't mind the ups and downs, I don't like the brake/ accelerate/ brake/ accelerate etc. I had a IH Scout II and it was a stick shift without power steering. It wore me out driving in the mountains, now all the vehicles are, AT and PS. I guess my point is that the mountains are lovely and the roads that have no guard rails are fine, if UPS can travel them everyday, so can you. If you are just afraid, like my wife and DGD, go to sleep, take a muscle relaxant and sit back and relax. Heck, I wish my wife could drive those parts, I would love to be able to just look and enjoy the countryside.
As an aside, the first time my DW drove the MoHo was fine, we were in Alberta's wheat fields, the second time we were on the Alaska Hwy and she almost ran us into a gully. After that I watched everything she did and it seemed she was driving way too far to the right. That scares me and I jerked and twitched while she drove. Because I don't like to do that, it makes her nervous, I decided to find out how far right she really drive. I would look at the white shoulder line and then in the sideview mirror. Soon I could tell when the "wheels" were over the should line and when she was in her lane. Turns out she had the same problem when I drove. Now I know that she really was in her lane and not on the shoulder. Now when she hits the warning strip, it doesn't scare me, but it sure ruins my napping.