Syracuse to Ellsworth ME (just north of ANP) is about a 10 hours straight drive doing 70 mph. Believe there are tolls in NH and ME as well. Currently, diesel is cheaper on the T-way than at Pilot/Loves truck stops. Same w/ Mass pike fuel. 2 years ago we left Syr w/ full tank of fuel. Stopped at Love's on NY/MA line to top off & scale out (had a '15 F350 w/ 3.55 gears then). Stopped again at the TA in NH ($) and last fuel stop was in ME at Dysarts outside of Bangor before heading towards BH. Traffic as mentioned was pretty heavy NW and N of Boston until you got into ME and past 1st toll booths, then it started to lesson.
If you wish to perhaps extend your 1st day of driving some, Junis Ponds (Geneva NY area) has a CG right next to the T-way or Verona (exit 33), Villages @ Turning Stone RV park (about 2-3 miles from t-way exit).
As mentioned too, Binghamton area is under construction at 17/86/81 interchange, but shouldn't have any problem getting onto 81 to 88. I was just on 88 last week for work and the right lane stunk pretty much all the way to 90. Had areas of recent re-paving, but that was like between Sidney and Oneonta (home of Brooks BBQ chicken, M-M-GOOD). 88 also has a couple very good hills to pull and fuel stop at exit 12 and a Pilot just before you get onto 90. Boring yet kinda pretty drive.