Route 40 Colorado eastern end out of Empire heading west

As mentioned, there are some steep twisty sections of 40 over Berthoud Pass. Its doable but since you're continuing to Kremmling, its easily avoided by staying on 70 to Silverthorne and using the much easier hwy 9 north to Kremmling.
Mid Oct to mid Nov you just need to watch the forecast and adjust your schedule to avoid any major storm passing through. The difference between blue sky & sunshine or a blizzard can change in 24 hrs.