You aren't leaving from Detroit, you are leaving from New Boston. So run I-275 to I-75 just watch out that you don't get into the "Exit Only" lane at Telegraph. Run south to Alexis Road, the first exit in Ohio and use GasBuddy to figure out who's fuel you buy. Get back on I-75 south and watch for I-280. You have to pay attention because they are doing some construction. Get off I-280 at Exit 6 and pick up OH-51 for a FEW blocks. Watch for OH579 on the left at a light. Take 579 though Williston Do Not Speed (it is 35 in town), until 579 meets OH-2. 2 is a good road and in less than 10 miles it will be limited access all the way to Elyria. There, it will dump you right onto I-90. Run I-90 right through Cleveland. Yes, it is a city and the people are all crazy. Just drive a speed you are comfortable and let them go around you... There are 3 interchanges in Cleveland, but they are well signed - Just stay with I-90 EAST. In a dozen more miles you will be out of Cleveland.. About Euclid, there is another interchange, STAY WITH I-90 EAST.
There is a Loves at Exit 241. Buy more fuel there whether you want to or not. You get to save .020/gal.
After Erie, watch for I-86. You can stay with I-86 to Painted Post and save the NY Toll$.
We go this way a lot, but I haven't actually been to the Glen is many a year...
Matt