I was on the Kanc just a few weekends ago. I don't think it would be a particular problem for you. There's only one or two really sharp switchbacks, and they're well marked with "slow down" sorts of signs. RVs of all descriptions and tour busses regularly go over it, and a number of the various pull-offs have parking for large rigs. (By the same token, at least one or two are marked for cars only with good reason.)
This time of year, nobody is going to be going super fast over it because everybody is going to be on it, moseying along, and looking at the leaves. You would not be making great time even in a car.
As s1214 mentioned, 302 is also a pretty drive, and not quite so curvy. I prefer the Kanc, but both are lovely.
