Although we live in NC, we started our Alaska trip from Tallahassee FL in early May. Weather plays a big part in trip planning and if you leave early,(April-May) you may want to follow Joe's suggestion and use I-10 while keeping yourself informed of what is going on north of you. I-90, I-80, I-70, and even I-40 can have snow delays well into June. Tornado's and/or strong winds are also a concern when traveling in the spring. This is not be discouraging about your trip, just keep in mind that you may not be able to follow the exact route that you have planned. lizzie