route through Appalachians from Buffalo NY

We are planning on traveling on US-219 S from Buffalo to Washington DC using the following route. I drove through the Appalachians years ago in a car and I don't really remember all that well how the elevation was. Now that we will be towing a trailer, I am giving it a little more thought, just to be safe. I wonder if anyone familiar with the following route could advise if there are any particularly steep sections etc. that I should be aware of on this route starting on US-219 S.

-US-219 S

-NY-417 E/US-219 BUS S/Wildwood Ave

-Continue to follow NY-417 E/US-219 BUS S

-Turn right onto US-219/US-219 S

-Continue to follow US-219 S

-Entering Pennsylvania

-Turn left onto PA-321 S/US-219 S/Buena Vista Hwy

-Continue to follow US-219 S

-Turn left onto Main St

-Continue onto US-219 S/Boot Jack Rd

-Continue to follow US-219 S

-Turn left onto PA-153 S/Penfield Rd

-Continue to follow PA-153 S

-Turn left to merge onto I-80 E

-Take exit 123 to merge onto PA-970 S/Shawville Hwy toward Woodland

-Turn left onto US-322 E/Woodland Bigler Hwy

-Continue to follow US-322 E

-Continue onto N 3rd St/N Centre St

-Continue to follow N Centre St

-Continue onto PA-350 S/Tyrone Pike

-Continue to follow PA-350 S

-Keep right at the fork, follow signs for US-220 S/I-99 S and merge onto I-99 S/US-220

-Take exit 1 toward I-70/I-76

-Merge onto US-220 BUS S

-Turn right onto the Pennnsylvania Turn Pike ramp

-Take exit 161 - 359 on the left for Interstate 76 E/Interstate 70 E toward Harrisburg

-Merge onto I-76 E

-Take exit 161 to merge onto I-70 E toward US-30/Breezewood/Baltimore

-Turn left to stay on I-70 E

-Take exit 53 to merge onto I-270 S toward Washington

Many thanks