Earl E noted that 66 is windy. NV 140 can also be windy.
Here is a brochure on the Winnemucca to the Sea Highway.
One can make the trip in a day. However, if you want to stay overnight, there are a couple of interesting options in NV. The Sheldon National Wildlife Refuge (
link with info) is right off the road. There is primitive Virgin Valley CG with a warm 92 degree pond to swim in! Also water, primitive showers, and pit toilets. We've driven by but never stopped, but from the description, it might be an interesting if not stark place to visit. Found
this video online that shows the CG, shower house, and pond.
A little further off the road from the road and beyond Virgin Valley CG there is the
Royal Peacock Opal Mine and RV Park. They do have hookups and the chance to look for opals. Again, never been there so can't comment on what you get for your $.